Regenerative Therapy by Dr. Brian Siegel, MD

  Contact : 970-819-1932

What is Regenerative Therapy?

Regenerative Therapy is an exciting, game-changing and innovative area of medicine that utilizes biological therapies to amplify the body’s natural ability to heal itself.



State of the art cell processing units concentrate the patient’s own blood into platelet-rich plasma (PRP).  This plasma is injected into damaged tissue offering an effective yet minimally invasive treatment option to relieve pain and other symptoms caused by the damage. By increasing the bodies’ natural healing abilities, patients enjoy a quicker and systematic healing process that relieves symptoms and allows them to return to their regular activities.


Tissue Matrix Grafts are used to treat more severe orthopedic problems. These grafts contain autologous mesenchymal stem cells that are directly injected into the injured or diseased area. Conditions for which tissue matrix grafting may be effective include:

  • Osteoarthritis in a joint;
  • Osteochondral defect (damaged cartilage or bone within a joint);
  • Muscle, tendon or ligament tear;
  • Lumbar disc disease and facet arthritis
  • Labral injuries of the shoulder and hip

Your body has two sources from which we obtain the necessary autologous stem cells: bone marrow and/or fat.

Mesenchymal Stem Cells from Adipose: Fat or adipose tissue is an excellent source of autologous stem cells. To obtain these cells, we perform a mini-liposuction. First, we prep and drape the area sterilely.   Then local anesthetic is used to numb the area from which the fat is to be extracted to minimize discomfort. A small cannula is inserted into the site to obtain adipose tissue. Depending on the severity of the condition to be treated, we may extract as little as 10 to 20 cc of fat or as much as 50 to 60 cc of fat. After the adipose tissue is extracted we subject it to a process of simple centrifugation. This process allows the local anesthetic and blood to be separated from the fat cells. Using either ultrasound or fluoroscopic guidance, we inject the adipose derived stem cells into the injured area. The procedure time is typically 1-2 hours.


Mesenchymal Stem Cells from Bone Marrow:A bone marrow aspirate (BMA) is typically done by taking a small amount of bone marrow from the back of your pelvis. After numbing the area thoroughly with local anesthetic, we insert a syringe through a cannula and draw out the bone marrow aspirate. After extracting the bone marrow, it is centrifuged in an FDA approved device to concentrate the bone marrow and receive a predictable number of stem cells and growth factors.  Using ultrasound or fluoroscopic guidance to ensure the precise location of injury, we inject the concentrated cells into the area to be treated.

The procedures do not require sedation; however, oral sedation is available to patients who request it.



Prolotherapy promotes long-term, often permanent pain relief by stimulating the body’s ability to repair itself. A solution of concentrated dextrose and local anesthetic (steroids are not used) is injected into the affected ligaments, tendons, or joint capsules. This solution acts not as a nutrient, but by stimulating the body’s natural ability to repair these tissues, encouraging growth of new ligament or tendon fibers.

Multiple treatments encourage additional tissue growth to restore and strengthen the affected area. An individual plan is devised with prolotherapy treatments scheduled every two to six weeks until the healing is complete, and you can return to normal activities without pain. The total appointment time takes approximately 30 minutes, including preparation, treatment and recovery time.



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